The overarching goal of the lab is to redefine membrane enzymology. Membrane enzymes are intricate protein machineries that catalyze reactions within the membrane and play critical roles in processes such as signaling, morphogenesis, and transcription. They are also implicated in diseases like cancer and Alzheimer’s. However, compared to other membrane proteins, membrane enzymes remain relatively understudied, limiting their potential as therapeutic targets. This gap in knowledge arises from their inherent functional complexities. For instance, gamma secretase, a prominent target for Alzheimer’s research, has over 90 known substrates, making its mechanisms challenging to unravel. The lab aims to overcome these challenges by developing specific probes to better understand these enzymes. By integrating a fundamental understanding of protein dynamics through cryo-EM and a robust searching system via virtual screening, we strive to shed light on the complexities of membrane enzymology and unlock new therapeutic opportunities.